Postbiotics and Immunity: Key Findings from 2025 to 2026 Studies
The past two years have brought significant advancements in our understanding of how postbiotics influence the immune system—without the need to introduce live microorganisms.
Key Research Highlights
- Emerging reviews and studies (2025) highlight postbiotics’ role in immune modulation, reducing inflammation, and supporting gut barrier function
- Increases in secretory IgA and overall mucosal immunity observed in multiple preclinical and clinical models
- Activation of NK cells and enhanced cytotoxicity confirmed in recent investigations involving inactivated Lactobacillus strains
- Reduction in pro-inflammatory cytokines (IL-6, TNF-α) during low-grade chronic inflammation, ranging from 15–35% in various trials
Why Postbiotics May Offer Advantages Over Live Probiotics for Immune Support
The primary immune effects stem from cell wall components (peptidoglycan, lipoteichoic acids) and DNA CpG motifs—these remain fully intact after heat inactivation, providing consistent benefits with greater stability and safety.
Key Takeaway
As of 2026, postbiotics are building one of the strongest evidence bases among interventions for daily immune support—particularly during cold and flu season or for individuals prone to frequent acute respiratory infections (ARIs).